Dear NIH-Korean Scientists, 

We will have the 6th NIH-KSA seminar on August 14 (This Wed). Lunch will be provided by Psomagen, Inc.

We hope to see you there!

여섯번째 NIH-KSA세미나가 이번주 수요일8월14일에 있을 예정입니다. 

Psomagen, Inc이 점심 제공합니다. 여러분의 많은 참여 부탁드립니다. 

Time (강연시간): August 14 Wed), 12:30-1:30 PM (45 min seminar, 15 min Q&A) 

장소:  Campus, Building 10, FAES Room 1-2

SPEAKER INFORMATION

Name(성함):  Byung Min Chung (정병민)

Position and Department (직장과 직함): Assistant Professor, Department of Biology, The Catholic University of America

Seminar Title (강연제목):

Keratin 19 regulates cell cycle pathway and sensitivity of breast cancer cells to CDK inhibitors 

Abstract (초록)

Keratin 19 (K19) belongs to a keratin family of proteins, which maintains structural integrity of epithelia. In cancer, K19 is highly expressed in several types where it serves as a diagnostic marker. Despite the positive correlation between higher expression of K19 in tumor and worse patient survival, the role of K19 in breast cancer remains unclear. Therefore, we ablated K19 expression in MCF7 breast cancer cells and found that K19 was required for cell proliferation. of KRT19 knockout cells identified defects in cell cycle progression and levels of target genes of E2F1, a key transcriptional factor the transition into S phase. Furthermore, proper levels of cyclin dependent kinases (CDKs) and including D-type cyclins critical for E2F1 activation, were dependent on K19 expression, and K19- D co-expression was observed in human breast cancer tissues. Importantly, K19 interacts with cyclin D3, and a loss of K19 resulted in of cyclin D3 and sensitivity of cells towards -induced cell death. Overall, these findings reveal a novel function of K19 in the regulation of and suggest that K19 may be used to predict the efficacy of CDK inhibitors for treatments of breast cancer.